Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma

Cancer Cell. 2012 Jan 17;21(1):1-3. doi: 10.1016/j.ccr.2011.12.011.


The capacity for self-renewal is thought to be a critical property of tumor-initiating cells. This capacity is often associated with the ability to generate spheres in vitro. In this issue of Cancer Cell, Barrett et al. show that cells lacking sphere-forming ability can still be very efficient at propagating tumors.

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