Cancer Gene Discovery in the Mouse

Curr Opin Genet Dev. 2012 Feb;22(1):14-20. doi: 10.1016/j.gde.2011.12.003. Epub 2012 Jan 20.


Developments in high-throughput genome analysis and in computational tools have made it possible to rapidly profile entire cancer genomes with basepair resolution. In parallel with these advances, mouse models of cancer have evolved into powerful tools for cancer gene discovery. Here we discuss some of the approaches that may be used for cancer gene identification in the mouse and discuss how a cross-species 'oncogenomics' approach to cancer gene discovery represents a powerful strategy for finding genes that drive tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Genes, Neoplasm*
  • Genome
  • Genomics
  • Humans
  • Mice
  • Mutagenesis
  • Neoplasms / genetics*