Ways and means of eukaryotic mRNA decay

Biochim Biophys Acta. 2012 Jun;1819(6):593-603. doi: 10.1016/j.bbagrm.2012.01.001. Epub 2012 Jan 12.


Messenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment and assembly of mRNP complexes enhance and bring specificity to mRNA decay. mRNP complexes can form larger structures that have been found to be ubiquitous in nature. Discovery of P-Bodies, an archetype of this sort of aggregates, has generated interest in the question of where mRNA degrades. This is currently an open question under extensive investigation. This review will discuss in detail the recent developments in the regulation of mRNA decay focusing on yeast as a model system. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus*
  • DEAD-box RNA Helicases / chemistry
  • DEAD-box RNA Helicases / genetics
  • Eukaryotic Cells
  • Membrane Transport Proteins / chemistry
  • Membrane Transport Proteins / metabolism
  • Molecular Conformation
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / metabolism
  • Nucleocytoplasmic Transport Proteins / chemistry
  • Nucleocytoplasmic Transport Proteins / genetics
  • Nucleocytoplasmic Transport Proteins / metabolism
  • Protein Structure, Tertiary
  • RNA Stability / genetics*
  • RNA, Messenger* / chemistry
  • RNA, Messenger* / genetics
  • RNA, Messenger* / metabolism
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / metabolism
  • Ribonucleoproteins* / chemistry
  • Ribonucleoproteins* / genetics
  • Ribonucleoproteins* / metabolism
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism


  • MEX67 protein, S cerevisiae
  • Membrane Transport Proteins
  • Mtr2 protein, S cerevisiae
  • Nuclear Proteins
  • Nucleocytoplasmic Transport Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • Saccharomyces cerevisiae Proteins
  • messenger ribonucleoprotein
  • DBP5 protein, S cerevisiae
  • DEAD-box RNA Helicases