Diffusion tensor and dynamic susceptibility contrast MRI in glioblastoma

Clin Neurol Neurosurg. 2012 Jul;114(6):607-12. doi: 10.1016/j.clineuro.2011.12.022. Epub 2012 Jan 21.


Objective: We prospectively investigated the correlation between diffusion tensor (DTI), dynamic susceptibility contrast (DSC) perfusion MRI metrics and Ki-67 labelling index in glioblastomas.

Methods: We studied seventeen patients who were operated on for glioblastoma. DTI and DSC MRI were performed within a week prior to surgical excision. Lesion/normal ratios were calculated for the apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF) and relative mean transit time (rMTT) ratio. In the excised tumour specimens Ki-67 antigen expression was evaluated by the MIB-1 immunostaining method.

Results: A significant correlation was observed between Ki-67 index and ADC ratio (r = -0.528, p = 0.029) and FA ratio (r = 0.589, p = 0.012). rCBV and rMTT presented a trend towards significant correlation with Ki-67 index (r = 0.628, p = 0.07 and r = 0.644, p = 0.06 respectively). There was a trend towards better survival for patients with gross total tumour excision and FA values lower than 0.48 (p = 0.1 and p = 0.09 respectively). No significant correlation was found between ADC ratio, rCBV, rCBF, rMTT and overall survival.

Conclusion: ADC ratio, FA ratio, rCBV and rMTT tumour/normal tissue ratios may represent indicators of glioma proliferation. FA values may hold promise for predicting survival in patients with glioblastoma.

MeSH terms

  • Aged
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery
  • Diffusion Tensor Imaging / methods*
  • Female
  • Glioblastoma / pathology*
  • Glioblastoma / surgery
  • Humans
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Ki-67 Antigen
  • Male
  • Middle Aged
  • Neurosurgical Procedures
  • Prognosis
  • Prospective Studies
  • ROC Curve
  • Survival Analysis


  • Ki-67 Antigen