A family business: stem cell progeny join the niche to regulate homeostasis

Nat Rev Mol Cell Biol. 2012 Jan 23;13(2):103-14. doi: 10.1038/nrm3272.

Abstract

Stem cell niches, the discrete microenvironments in which the stem cells reside, play a dominant part in regulating stem cell activity and behaviours. Recent studies suggest that committed stem cell progeny become indispensable components of the niche in a wide range of stem cell systems. These unexpected niche inhabitants provide versatile feedback signals to their stem cell parents. Together with other heterologous cell types that constitute the niche, they contribute to the dynamics of the microenvironment. As progeny are often located in close proximity to stem cell niches, similar feedback regulations may be the underlying principles shared by different stem cell systems.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division / genetics
  • Cell Division / physiology
  • Cell Movement / genetics
  • Cell Movement / physiology
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / physiology
  • Homeostasis / genetics
  • Homeostasis / physiology*
  • Humans
  • Models, Biological
  • Organ Specificity / genetics
  • Organ Specificity / physiology
  • Signal Transduction / genetics
  • Signal Transduction / physiology
  • Stem Cell Niche* / genetics
  • Stem Cell Niche* / physiology
  • Stem Cells / cytology*
  • Stem Cells / physiology*