Nanochemoprevention by Encapsulation of (-)-epigallocatechin-3-gallate With Bioactive peptides/chitosan Nanoparticles for Enhancement of Its Bioavailability

Chem Commun (Camb). 2012 Feb 28;48(18):2421-3. doi: 10.1039/c2cc17295j. Epub 2012 Jan 23.

Abstract

Nanochemoprevention by oral consumption was developed by the encapsulation of (-)-epigallocatechin-3-gallate (EGCG) with nanoparticles that were electrostatically assembled from bioactive caseinophosphopeptides and chitosan, which was highly biocompatible and able to enhance the bioavailability of EGCG.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biological Availability
  • Caco-2 Cells
  • Capsules
  • Catechin / analogs & derivatives*
  • Catechin / chemistry
  • Catechin / pharmacokinetics
  • Chemoprevention
  • Chitosan / chemistry*
  • Drug Carriers / chemistry*
  • Humans
  • Nanoparticles / chemistry*
  • Peptide Fragments / chemistry*

Substances

  • Capsules
  • Drug Carriers
  • Peptide Fragments
  • Catechin
  • Chitosan
  • epigallocatechin gallate