Thalamic Control of Cortical States

Nat Neurosci. 2012 Jan 22;15(3):370-2. doi: 10.1038/nn.3035.

Abstract

We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Afferent Pathways / physiology
  • Animals
  • Channelrhodopsins
  • Cortical Synchronization / physiology*
  • Denervation
  • Electric Stimulation / methods
  • Fourier Analysis
  • Mice
  • Mice, Transgenic
  • Neurons / physiology
  • Somatosensory Cortex / cytology
  • Somatosensory Cortex / physiology*
  • Thalamus / cytology
  • Thalamus / physiology*
  • Vibrissae / innervation
  • Wakefulness

Substances

  • Channelrhodopsins