Transcription factor RORα is critical for nuocyte development

Nat Immunol. 2012 Jan 22;13(3):229-36. doi: 10.1038/ni.2208.

Abstract

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation*
  • Interleukin-7 / immunology
  • Interleukin-7 / metabolism
  • Leukocytes / cytology
  • Leukocytes / immunology*
  • Leukocytes / metabolism
  • Mice
  • Nippostrongylus / immunology
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / immunology*
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / metabolism
  • Signal Transduction
  • Strongylida Infections / immunology
  • Thymocytes / immunology

Substances

  • Interleukin-7
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Rora protein, mouse