Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones

E Fink; C Hehlein-Fink; M Eulitz

doi:10.1016/0014-5793(90)81273-q

Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones

FEBS Lett. 1990 Sep 17;270(1-2):222-4. doi: 10.1016/0014-5793(90)81273-q.

Authors

E Fink¹, C Hehlein-Fink, M Eulitz

Affiliation

¹ Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, FRG.

PMID: 2226783
DOI: 10.1016/0014-5793(90)81273-q

Abstract

The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone beta-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrosin / antagonists & inhibitors*
Amino Acid Sequence
Glycoproteins / chemistry
Hormones / chemistry
Humans
Molecular Sequence Data
Semen / chemistry
Sequence Homology, Nucleic Acid
Serine Peptidase Inhibitors, Kazal Type
Trypsin Inhibitor, Kazal Pancreatic / chemistry*
Trypsin Inhibitors / chemistry*

Substances

Glycoproteins
Hormones
SPINK2 protein, human
Serine Peptidase Inhibitors, Kazal Type
Trypsin Inhibitors
Trypsin Inhibitor, Kazal Pancreatic
Acrosin