Modulatory influence of rarely repeated of immobilization episodes on the interleukin-1β-dependent reaction of blood leukocytes and hepatoprotective effect of restraint stress

O B Tseilikman; V E Tseilikman; A V Linin; D A Gubkin; E A Rudina; S A Trubetskoy; P V Ivanov; E A Pozdnyakov

doi:10.1007/s10517-011-1154-x

Modulatory influence of rarely repeated of immobilization episodes on the interleukin-1β-dependent reaction of blood leukocytes and hepatoprotective effect of restraint stress

Bull Exp Biol Med. 2011 Feb;150(4):409-11. doi: 10.1007/s10517-011-1154-x.

Authors

O B Tseilikman¹, V E Tseilikman, A V Linin, D A Gubkin, E A Rudina, S A Trubetskoy, P V Ivanov, E A Pozdnyakov

Affiliation

¹ South Ural State University, Chelyabinsk, Russia. vadimed@yandex.ru

PMID: 22268029
DOI: 10.1007/s10517-011-1154-x

Abstract

Repeated episodes of 1-h restraint stress were accompanied by a decrease in the sensitivity of blood leukocytes and cytochrome P450-dependent monooxygenases of the liver to recombinant IL-1β. These changes are associated with the anti-inflammatory hepatoprotective effect of chronic stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytochrome P-450 Enzyme System / metabolism*
Female
Interleukin-1beta / administration & dosage
Interleukin-1beta / pharmacology*
Leukocytes / drug effects
Leukocytes / metabolism*
Liver / metabolism*
Male
Rats
Restraint, Physical
Stress, Physiological
Stress, Psychological

Substances

Interleukin-1beta
Cytochrome P-450 Enzyme System