Clinical effect of a mouth rinse containing Ocimum gratissimum on plaque and gingivitis control

J Contemp Dent Pract. 2011 Sep 1;12(5):350-5.


Aim: The effect of Ocimum gratissimum (Og) on the reduction of dental plaque and gingivitis was evaluated in a randomized, parallel and double-blind clinical trial.

Materials and methods: Subjects were randomly allocated to the control group (n=10)-mouth rinse with no antiseptic agents; CLX group (n=10)-mouth rinse containing chlorhexidine digluconate or Og group (n=10)-mouth rinse containing Ocimum gratissimum. Plaque (PLI) and bleeding (BI) indexes were assessed at days 0 and after 3 months. Subjects were asked to brush their teeth with a fluoridated dentifrice, three times a day, during a 90-day period. After each brushing they rinsed with one of the three mouth rinses during 1 minute.

Results: There was a significant reduction on plaque and gingivitis in tests groups (p < 0.05), but no statistically significant difference was observed among them (p > 0.05).

Conclusion: Mouth rinse containing Og was effective as antiplaque and antigingivitis agent, in a similar manner that chlorhexidine digluconate.

Clinical significance: Research in treatment of chronic oral diseases using natural agents must be encouraged to verify which would be a useful addition to the current range of chemotherapeutic treatment options.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Infective Agents, Local / therapeutic use*
  • Chlorhexidine / analogs & derivatives
  • Chlorhexidine / therapeutic use
  • Dental Plaque / classification
  • Dental Plaque / prevention & control*
  • Dental Plaque Index
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Gingivitis / classification
  • Gingivitis / prevention & control*
  • Humans
  • Male
  • Mouthwashes / therapeutic use*
  • Ocimum*
  • Periodontal Index
  • Phytotherapy*
  • Plant Preparations / therapeutic use*


  • Anti-Infective Agents, Local
  • Mouthwashes
  • Plant Preparations
  • chlorhexidine gluconate
  • Chlorhexidine