Successful management of bleeding after dental procedures with application of blood stopper: a single center prospective trial

J Contemp Dent Pract. 2011 Sep 1;12(5):379-84. doi: 10.5005/jp-journals-10024-1063.


Aim: Ankaferd Blood Stopper (ABS), as an herbal complementary medicine, has been approved for the management of clinical hemorrhages in Turkey, including dental interventions. Basic, preclinical and clinical studies disclosed the settings of the topical hemostatic use of ABS. The aim of this study is therefore to assess the efficacy and safety of ABS as an antihemorrhagic agent in the bleedings associated with dental procedures in patients with normal and impaired hemostasis.

Materials and methods: ABS has been topically applied by homogeneously spraying to the 113 patients during dental interventions within its on-label indications. A median of 0.5 ml (IQR:0.5-1 ml) ABS was administered after tooth extraction with prolonged hemorrhages.

Results: After the administration, bleeding stopped in less than 10 seconds in 59 (52.2%) patients, and below 22.5 seconds (IQR: 18, 8-30) in 54 patients (47.8%). A total of 141 procedures were performed in these 113 patients, and nearly 72.5 ml ABS was used with a total cost of 98 €.

Conclusion: ABS as a new herbal medicine was found to be an effective method for controlling bleeding related to dental procedures. No patient had wound infection and the healing process appeared to be normal. Topical ABS could be useful for the local hemostasis and wound healing in periodontal surgeries.

Clinical significance: In this prospective study ABS, for the first time, has demonstrated its potential for being an effective hemostatic agent for the management of bleedings due to dental procedures.

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aerosols
  • Aged
  • Alveoloplasty
  • Child
  • Drug Costs
  • Female
  • Hemostatics / administration & dosage
  • Hemostatics / economics
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / surgery
  • Oral Hemorrhage / drug therapy*
  • Oral Surgical Procedures*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / economics
  • Plant Extracts / therapeutic use*
  • Prospective Studies
  • Radicular Cyst / surgery
  • Safety
  • Time Factors
  • Tooth Extraction
  • Tooth, Impacted / surgery
  • Treatment Outcome
  • Young Adult


  • Aerosols
  • Hemostatics
  • Plant Extracts
  • ankaferd blood stopper