What is complex about complex disorders?

Genome Biol. 2012 Jan 23;13(1):237. doi: 10.1186/gb-2012-13-1-237.


Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes.

MeSH terms

  • Genetic Association Studies
  • Genetic Diseases, Inborn / genetics*
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study*
  • Humans
  • Multifactorial Inheritance
  • Mutation
  • Quantitative Trait, Heritable