Cost-benefit analysis of in-hospital influenza vaccination of postpartum women

Obstet Gynecol. 2012 Feb;119(2 Pt 1):306-14. doi: 10.1097/AOG.0b013e318242af27.


Objective: To estimate the potential economic benefits associated with hospital-based postpartum influenza vaccination.

Methods: We constructed a decision analysis model to estimate the potential cost benefit of this strategy from both a societal perspective and a third-party perspective. We included a hypothetical cohort of 1.47 million U.S. postpartum women, assuming an influenza season beginning September 1 and ending April 30. Probabilities and costs were derived from published literature, Centers for Disease Control and Prevention data, and expert recommendations. We used one-way and two-way sensitivity analyses. All cost estimates were inflated to year 2010 U.S. dollars and discounted at a 3% annual discount rate.

Results: From the societal perceptive, the expected costs per vaccinated and unvaccinated mother were $328.45 and $341.02 respectively, resulting in an expected net benefit of $12.57 per vaccinated mother. The overall savings in the cohort were predicted to range from $3.69 to $14.75 million, depending on the vaccination coverage rate. This strategy would be cost-beneficial, holding all other variables to the base case, if the annual maternal influenza attack rate is more than 2.8%, influenza vaccine efficacy is more than 47%, or if vaccine acquisition and administration cost per dose are less than $32.78. The strategy would not generate net savings from the third-party perspective. Sensitivity analyses were robust, but disease incidence and vaccine efficacy were important drivers.

Conclusion: Our model suggests that postpartum influenza vaccination is a cost-beneficial approach for prevention of maternal and infantile influenza from a societal perspective.

Level of evidence: III.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cost-Benefit Analysis
  • Decision Support Techniques
  • Female
  • Health Care Costs / statistics & numerical data*
  • Hospitalization
  • Humans
  • Influenza, Human / economics*
  • Influenza, Human / prevention & control*
  • Insurance, Health, Reimbursement / economics
  • Models, Econometric*
  • Postpartum Period
  • Pregnancy
  • Probability
  • United States
  • Vaccination / economics*