Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient

Mod Rheumatol. 2012 Sep;22(5):783-6. doi: 10.1007/s10165-011-0576-7. Epub 2012 Jan 21.

Abstract

We present the case of a 43-year-old man diagnosed with HLA-B39-positive spondyloarthritis who developed cutaneous lesions consistent with cutaneous polyarteritis nodosa (CPN). Previous studies indicated an elevated incidence of HLA-B39 in HLA-B27-negative Japanese patients with spondyloarthritis. This case suggested that CPN may also occur in association with forms of HLA-B39-positive spondyloarthritis. The rarity of this association is emphasized. Therapy with corticosteroid and methotrexate improved both the cutaneous lesions and the clinical symptoms of spondyloarthritis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers / blood
  • Glucocorticoids / therapeutic use
  • HLA-B39 Antigen / blood*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Methotrexate / therapeutic use
  • Polyarteritis Nodosa / complications*
  • Polyarteritis Nodosa / diagnosis
  • Polyarteritis Nodosa / drug therapy
  • Prednisolone / therapeutic use
  • Skin / blood supply
  • Skin / pathology
  • Skin Diseases
  • Spondylarthritis / complications*
  • Spondylarthritis / diagnosis
  • Spondylarthritis / drug therapy
  • Treatment Outcome

Substances

  • Biomarkers
  • Glucocorticoids
  • HLA-B39 Antigen
  • Immunosuppressive Agents
  • Prednisolone
  • Methotrexate