Diabetes and foot infection: more than double trouble

Diabetes Metab Res Rev. 2012 Feb:28 Suppl 1:46-53. doi: 10.1002/dmrr.2234.


Background: Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them.

Methods: This article reviews these factors, in the light of data from the literature and from our own results.

Results: DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms.

Conclusion: The development of new tools from molecular biology is a critical step to better understand and manage these infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diabetes Complications*
  • Diabetes Mellitus / physiopathology*
  • Diabetic Foot / complications
  • Diabetic Foot / microbiology*
  • Diabetic Foot / therapy
  • Humans
  • Wound Infection / diagnosis
  • Wound Infection / microbiology*
  • Wound Infection / therapy