Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies

PLoS Biol. 2012 Jan;10(1):e1001244. doi: 10.1371/journal.pbio.1001244. Epub 2012 Jan 17.


A set of software tools for building and distributing models of macromolecular assemblies uses an integrative structure modeling approach, which casts the building of models as a computational optimization problem where information is encoded into a scoring function used to evaluate candidate models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology / methods*
  • Humans
  • Macromolecular Substances / chemistry*
  • Models, Molecular*
  • RNA Polymerase II / chemistry
  • Software*


  • Macromolecular Substances
  • RNA Polymerase II