A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical keloid/hypertrophic scar excision

Dermatol Surg. 2012 Jun;38(6):893-7. doi: 10.1111/j.1524-4725.2012.02345.x. Epub 2012 Jan 24.


Background: Published reports indicate that corticosteroid injections can prevent recurrence after keloid excision, but the side effects of repetitive intralesional steroid injections may preclude treatment maintenance. Additionally, few of these studies employed a standardized treatment protocol.

Objectives: To analyze the results of a new uniform treatment protocol combining corticosteroid injections and ointment application designed to reduce recurrence rates after excisional surgery in individuals with keloids or hypertrophic scars.

Methods: As a standard procedure, the first corticosteroid injection took place after removal of the sutures and then once every 2 weeks after that until it had been done five times. In addition, all postsurgical wounds received self-administered steroid ointment application twice daily for 6 months after suture removal.

Results: Postoperative follow-up in this series ranged from 24 to 57 months (median 32 months, mean 32.5 months). Recurrence occurred in three of the 21 keloid cases (14.3%) and one of the six hypertrophic scar cases (16.7%).

Conclusion: We evaluated a new standardized adjuvant corticosteroid therapy to prevent recurrence after surgical keloid or hypertrophic scar excision. Using this method, we achieved low recurrence rates.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Child
  • Cicatrix, Hypertrophic / drug therapy*
  • Cicatrix, Hypertrophic / etiology
  • Cicatrix, Hypertrophic / pathology
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage*
  • Humans
  • Injections, Intralesional
  • Keloid / drug therapy*
  • Keloid / etiology
  • Keloid / pathology
  • Male
  • Middle Aged
  • Ointments / administration & dosage*
  • Postoperative Complications
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Glucocorticoids
  • Ointments