The Relationship Between Optical Coherence Tomography Patterns, Angiographic Parameters and Visual Acuity in Age-Related Macular Degeneration

Int Ophthalmol. 2012 Feb;32(1):25-30. doi: 10.1007/s10792-012-9519-3. Epub 2012 Jan 25.


To assess the relationships between visual acuity (VA), fluorescein angiographic parameters and optical coherence tomography (OCT) patterns in exudative age-related macular degeneration (AMD). Fifty eyes with confirmed diagnosis of new exudative AMD who underwent fluorescein angiography (FA) and OCT evaluation were reviewed retrospectively. The greatest linear diameter of lesion (GLD) by FA and central foveal thickness (CFT) by OCT were measured. The OCT scans were evaluated for the presence of diffuse retinal thickening (D), cystic spaces (C), subretinal fluid (S) and pigment epithelial detachment (P) and five OCT patterns were detected (D + S; C; C + S; P + C + S; P + D + S). Angiographic classification of choroidal neovascularizations was performed. Correlations were statistically significant for VA and CFT in all patients whereas VA and GLD correlation was statistically significant only in predominantly classic and minimal classic lesions. The lowest VA values were detected in patients with COCT pattern and/or predominantly classic lesion type by FA. The OCT and FA findings when evaluated simultaneously may provide information regarding visual function in AMD.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Female
  • Fluorescein Angiography / methods*
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Macula Lutea / pathology*
  • Macular Degeneration / diagnosis*
  • Macular Degeneration / physiopathology
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Retrospective Studies
  • Severity of Illness Index
  • Tomography, Optical Coherence / methods*
  • Visual Acuity*