Abstract
Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Caspase Inhibitors*
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Humans
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Interleukin-1beta / biosynthesis
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Interleukin-1beta / drug effects
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Leukemia, Myeloid
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Molecular Structure
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Penicillium / chemistry*
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Polycyclic Sesquiterpenes
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology*
Substances
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Caspase Inhibitors
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Interleukin-1beta
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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berkedrimane A
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berkedrimane B
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drimane