Photodynamic therapy in a teenage girl with xeroderma pigmentosum type C

Pediatr Dermatol. 2012 May-Jun;29(3):373-4. doi: 10.1111/j.1525-1470.2011.01657.x. Epub 2012 Jan 26.


Despite aggressive sun protection, most individuals with xeroderma pigmentosum (XP) develop cutaneous neoplasia, including actinic keratoses. We describe the case of a 16-year-old girl with XP type C treated safely with photodynamic therapy (PDT). Although there is little if any evidence in the literature supporting the use of aminolevulinic acid PDT in individuals with XP, they may be the ideal candidates for PDT treatment because the profound post-treatment photosensitivity and strict post-therapy sun avoidance necessitated by PDT treatment is already part of the everyday lifestyle of people with XP.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aminolevulinic Acid / therapeutic use*
  • Aminoquinolines / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Arm
  • Face
  • Female
  • Fluorouracil / therapeutic use
  • Humans
  • Imiquimod
  • Keratosis / drug therapy
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use*
  • Skin Neoplasms / drug therapy
  • Sunlight / adverse effects
  • Treatment Outcome
  • Xeroderma Pigmentosum / drug therapy*


  • Aminoquinolines
  • Antineoplastic Agents
  • Photosensitizing Agents
  • Aminolevulinic Acid
  • Imiquimod
  • Fluorouracil