Allergic and immunologic reactions to food additives

Clin Rev Allergy Immunol. 2013 Aug;45(1):6-29. doi: 10.1007/s12016-012-8300-8.


For centuries, food additives have been used for flavouring, colouring and extension of the useful shelf life of food, as well as the promotion of food safety. During the last 20 years, the studies implicating the additives contained in foods and medicine as a causative factor of allergic reactions have been proliferated considerably. In this review, we aimed to overview all of the food additives which were approved to consume in EU and find out how common and serious allergic reactions come into existence following the consuming of food additives.

Publication types

  • Review

MeSH terms

  • Allergens / adverse effects*
  • Allergens / immunology
  • Animals
  • European Union
  • Food / adverse effects
  • Food Additives / adverse effects*
  • Food Hypersensitivity / epidemiology
  • Food Hypersensitivity / immunology*
  • Humans
  • Prevalence


  • Allergens
  • Food Additives