Erythroid and granulocytic colony growth in cultures supplemented with human serum lipoproteins

J Cell Physiol. 1979 May;99(2):233-8. doi: 10.1002/jcp.1040990210.


The ability of human serum to support erythroid and granulocytic colony formation has been investigated. It was found that normal human serum could replace fetal calf serum in the cultures and was able to support the growth of these hemopoietic colonies. Serum fractions enriched for low density lipoproteins, either by precipitation with Heparin-Mn++ or by ultracentrifugation, was found to contain this growth supporting activity of human serum.

MeSH terms

  • Bone Marrow Cells
  • Clone Cells / physiology*
  • Erythrocytes / physiology*
  • Granulocytes / physiology*
  • Growth Substances
  • Hematopoietic Stem Cells / cytology
  • Humans
  • Lipoproteins / blood
  • Lipoproteins / pharmacology*
  • Lipoproteins, LDL / pharmacology


  • Growth Substances
  • Lipoproteins
  • Lipoproteins, LDL