Multicentric giant cell tumor: metachronous central and peripheral involvement

Ear Nose Throat J. 2012 Jan;91(1):37-9. doi: 10.1177/014556131209100112.


Giant cell tumors are rare in the head and neck region. The most frequently involved sites of giant cell lesions in the head and neck are the maxilla and mandible, whereas the sphenoid and temporal bones are rarely involved. This tumor is usually located in the long bones of limbs. Reparative granuloma and brown tumor of hyperparathyroidism must be included in the differential diagnosis. Here we report the clinical and radiologic findings of a multicentric giant cell tumor with skull base involvement in a female patient. This case report demonstrates the similar pathophysiology of peripheral and central giant cell tumors.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / therapy
  • Carpal Bones
  • Female
  • Giant Cell Tumor of Bone / diagnosis*
  • Giant Cell Tumor of Bone / therapy
  • Humans
  • Humerus
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / therapy
  • Neoplasms, Second Primary / diagnosis*
  • Neoplasms, Second Primary / therapy
  • Sacrum
  • Skull Base Neoplasms / diagnosis
  • Skull Base Neoplasms / therapy