Wnt signaling: the β-cat(enin)'s meow

Genes Dev. 2012 Jan 15;26(2):105-9. doi: 10.1101/gad.185280.111.


In a study in the December 15, 2011, issue of Genes & Development, Valenta and colleagues (pp. 2631-2643) constructed a series of β-catenin mutants that allowed them to separate β-catenin's activity as a mediator of Wnt signaling from its activity as cell adhesion component. In doing so, they uncovered some surprising properties of Wnt signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental*
  • beta Catenin / genetics*
  • beta Catenin / metabolism*


  • beta Catenin