Abstract
A series of (2-aminothiazol-4-yl)methylester (5a-t) derivatives were synthesized in good yields and characterized by (1)H NMR, (13)C NMR, mass spectral and elemental analyses. The crystal structure of 5a was evidenced by X-ray diffraction study. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology*
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Antitubercular Agents / chemical synthesis
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Antitubercular Agents / chemistry*
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Antitubercular Agents / pharmacology*
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Bacteria / drug effects
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Bacterial Infections / drug therapy
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Crystallography, X-Ray
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Fungi / drug effects
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Humans
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Microbial Sensitivity Tests
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Models, Molecular
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Mycobacterium tuberculosis / drug effects
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Mycoses / drug therapy
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Thiazoles / chemical synthesis
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Thiazoles / chemistry*
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Thiazoles / pharmacology*
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Tuberculosis / drug therapy
Substances
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Anti-Infective Agents
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Antitubercular Agents
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Thiazoles