Evaluation of vitamin E in the treatment of erectile dysfunction in aged rats

Life Sci. 2012 Apr 9;90(13-14):489-94. doi: 10.1016/j.lfs.2011.12.019. Epub 2012 Jan 17.


Aims: The present study aims to elucidate the role of oxidative stress in erectile dysfunction associated with aging and to investigate the effect of treatment with vitamin E in this respect.

Main methods: Rats were divided into four groups: young (3-month-old), aged rats (18-month-old), aged rats given 80 IU of vitamin E/rat/day for 21-days, aged rats given 5mg/kg of sildenafil/day for 21-days. Intracavernosal pressure/mean arterial pressure (ICP/MAP), nitric oxide production, TBARS, GSH levels and SOD activity in corpus cavernosum were measured.

Key findings: Significant decrease in ICP/MAP was observed in aged rats at both low and high frequency of stimulation. Significant increase in ICP/MAP was observed in aged rats treated with vitamin E over the range of 0.8 to 5 Hz but young control values were not restored. Percentage potentiation of ICP/MAP than aged group at 0.8 Hz was 326±41.3% and 897±72.2% for vitamin E and sildenafil respectively. Decreased levels of NO(2)/NO(3) and SOD activity in the penile tissue observed with aging were elevated back to control by either vitamin E or sildenafil. Penile concentration of TBARS was 20.86±0.83 for aged rats vs. 11.39±0.79 nmol/g tissue for young controls. Both vitamin E and sildenafil reduced penile TBARS in aged rats.

Significance: This study proves that antioxidant therapy with vitamin E ameliorates the age-associated erectile dysfunction. Sildenafil may exert some antioxidant properties which add to the advantages of its long-term use. The effect of combinations of low-dose sildenafil and vitamin E on age-associated erectile dysfunction merits to be studied.

MeSH terms

  • Aging / physiology*
  • Animals
  • Antioxidants / therapeutic use*
  • Erectile Dysfunction / drug therapy*
  • Humans
  • Male
  • Oxidative Stress
  • Piperazines / therapeutic use
  • Purines / therapeutic use
  • Rats
  • Rats, Wistar
  • Sildenafil Citrate
  • Sulfones / therapeutic use
  • Vasodilator Agents / therapeutic use
  • Vitamin E / therapeutic use*


  • Antioxidants
  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Vitamin E
  • Sildenafil Citrate