Diabetes and hypertension: is there a common metabolic pathway?

Curr Atheroscler Rep. 2012 Apr;14(2):160-6. doi: 10.1007/s11883-012-0227-2.


Diabetes and hypertension frequently occur together. There is substantial overlap between diabetes and hypertension in etiology and disease mechanisms. Obesity, inflammation, oxidative stress, and insulin resistance are thought to be the common pathways. Recent advances in the understanding of these pathways have provided new insights and perspectives. Physical activity plays an important protective role in the two diseases. Knowing the common causes and disease mechanisms allows a more effective and proactive approach in their prevention and treatment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / physiopathology*
  • Female
  • Humans
  • Hypertension / epidemiology
  • Hypertension / physiopathology*
  • Insulin Resistance / physiology
  • Male
  • Metabolic Networks and Pathways / genetics
  • Metabolic Networks and Pathways / physiology*
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / physiopathology*
  • Motor Activity / physiology
  • Obesity / epidemiology
  • Obesity / physiopathology*
  • Oxidative Stress / physiology
  • Prevalence
  • Prognosis
  • Risk Assessment
  • Stress, Psychological