5-HT1A Receptors in major depression

J Psychopharmacol. 1990 Jan;4(2):69-74. doi: 10.1177/026988119000400204.


The 5-HT(1A) receptor has been studied using quantitative tritium film auto radiography in post-mortem frontal cortex of 15 cases suffering from major depression and controls matched for age, sex, post-mortem delay and storage time. 5-HT(1A) receptor binding in the depressive cohort was not significantly different from control values. No consistent effects of antidepressant medication or mental state at death were seen on the results.