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. 1990 Nov 15;46(5):871-7.
doi: 10.1002/ijc.2910460520.

Evidence for the Role of 34-kDa Galactoside-Binding Lectin in Transformation and Metastasis

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Evidence for the Role of 34-kDa Galactoside-Binding Lectin in Transformation and Metastasis

A Raz et al. Int J Cancer. .

Abstract

The endogenous Mr 34,000 galactoside-binding lectin (L-34) is found at elevated levels in a wide variety of neoplastic cells and correlative evidence suggests that it is involved in tumor metastasis in vivo and in transformation in vitro. We demonstrate here that introduction of recombinant L-34 into tumorigenic, weakly metastatic UV-2237-cl-15 fibrosarcoma cells results in an increased incidence of experimental lung metastases in syngeneic and nude mice. Transfection of normal BALB/c-A31 cloned fibroblasts with functional L-34 results in acquisition of anchorage-independent growth and in morphological transformation in vitro but not in tumorigenicity in vivo. These results provide direct evidence that the cellular expression of L-34 is associated with some aspects of transformation and with metastasis, but not with tumorigenicity per se.

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