Genotoxicity of ibuprofen in mouse bone marrow cells in vivo

Drug Chem Toxicol. 2012 Oct;35(4):389-92. doi: 10.3109/01480545.2011.630670. Epub 2012 Jan 27.


Genotoxicity of ibuprofen was evaluated by employing the mouse in vivo chromosomal aberration (CA) test. Ibuprofen administered orally at doses of 10, 20, 40, and 60 mg/kg body weight to mice resulted in mitotic depression and induction of CAs. A dose-related decrease in mitotic index (MI) and an increase in the frequencies of chromosomal aberrations per cell (CAs/cell) were recorded in bone marrow cells. However, a statistically significant reduction in MI and an increase in CAs/cell were found for both the higher doses. The results obtained indicate that ibuprofen is capable of inducing dose-dependent genotoxicity in bone marrow cells of mice.

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Bone Marrow Cells / drug effects*
  • Bone Marrow Cells / pathology
  • Chromosome Aberrations / chemically induced*
  • Dose-Response Relationship, Drug
  • Ibuprofen / administration & dosage
  • Ibuprofen / toxicity*
  • Mice
  • Mitosis / drug effects
  • Mitotic Index
  • Mutagenicity Tests
  • Mutagens / administration & dosage
  • Mutagens / toxicity*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Mutagens
  • Ibuprofen