Transcription regulation system mediated by mechanical operation of a DNA nanostructure

J Am Chem Soc. 2012 Feb 15;134(6):2852-5. doi: 10.1021/ja2074856. Epub 2012 Jan 31.


A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biotin / chemistry
  • DNA / chemistry*
  • DNA-Directed RNA Polymerases / chemistry
  • Disulfides
  • Gene Expression Regulation
  • Imaging, Three-Dimensional
  • Molecular Sequence Data
  • Nanocomposites
  • Nanotechnology / methods*
  • Nucleic Acid Conformation
  • Stress, Mechanical
  • Transcription, Genetic
  • Viral Proteins / chemistry


  • Disulfides
  • Viral Proteins
  • Biotin
  • DNA
  • bacteriophage T7 RNA polymerase
  • DNA-Directed RNA Polymerases