Abstract
A selective palladium-catalyzed Suzuki-Miyaura coupling reaction of polyfluorophenyl oxazolines through ortho C-F activation is described. It was found that reactions with DPPF as the ligand occurred much faster than those with other ligands. A variety of arylboronic acids including challenging functionalized arylboronic acids such as enolizable ketones, aldehyde, cyano, ester, and trifluoromethyl groups were tolerated with the reaction conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Boronic Acids / chemistry
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Carbon / chemistry*
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Catalysis
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Esters / chemistry
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Fluorine / chemistry*
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Hydrocarbons, Fluorinated / chemical synthesis*
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Ketones / chemistry
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Ligands
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Oxazoles / chemical synthesis*
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Palladium / chemistry*
Substances
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Aldehydes
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Boronic Acids
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Esters
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Hydrocarbons, Fluorinated
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Ketones
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Ligands
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Oxazoles
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Fluorine
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Palladium
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Carbon