Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease

Int J Tuberc Lung Dis. 2011 Oct;15(10):1415-20. doi: 10.5588/ijtld.10.0786.


Background: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD).

Objective: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD.

Design: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma.

Results: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age >65 years and higher serum sTREM-1 level were associated with worse 6-month survival.

Conclusion: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • Calcitonin / blood
  • Calcitonin Gene-Related Peptide
  • Chi-Square Distribution
  • Humans
  • Interferon-gamma / blood
  • Kaplan-Meier Estimate
  • Logistic Models
  • Lung Diseases / blood
  • Lung Diseases / diagnosis*
  • Lung Diseases / microbiology
  • Membrane Glycoproteins / blood*
  • Middle Aged
  • Multivariate Analysis
  • Mycobacterium Infections, Nontuberculous / blood
  • Mycobacterium Infections, Nontuberculous / diagnosis*
  • Mycobacterium Infections, Nontuberculous / microbiology
  • Mycobacterium avium / isolation & purification
  • Mycobacterium kansasii / isolation & purification
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • Protein Precursors / blood
  • Receptors, Immunologic / blood*
  • Risk Assessment
  • Risk Factors
  • Sensitivity and Specificity
  • Sputum / microbiology
  • Taiwan
  • Triggering Receptor Expressed on Myeloid Cells-1
  • Up-Regulation


  • Biomarkers
  • CALCA protein, human
  • Membrane Glycoproteins
  • Protein Precursors
  • Receptors, Immunologic
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1
  • Interferon-gamma
  • Calcitonin
  • C-Reactive Protein
  • Calcitonin Gene-Related Peptide