Medical management of hepatorenal syndrome

Nephrol Dial Transplant. 2012 Jan;27(1):34-41. doi: 10.1093/ndt/gfr736.


Hepatorenal syndrome (HRS) is defined as the occurrence of renal dysfunction in a patient with end-stage liver cirrhosis in the absence of another identifiable cause of renal failure. The prognosis of HRS remains poor, with a median survival without liver transplantation of <6 months. However, understanding the pathogenesis of HRS has led to the introduction of treatments designed to increase renal perfusion and mean arterial blood pressure using vasopressors and albumin, which has led to improvement in renal function in ∼50% of patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Disease Management*
  • Hepatorenal Syndrome / etiology*
  • Hepatorenal Syndrome / therapy*
  • Humans
  • Liver Cirrhosis / complications*
  • Liver Cirrhosis / therapy
  • Liver Transplantation / adverse effects*
  • Prognosis
  • Renal Insufficiency / etiology*
  • Renal Insufficiency / therapy