Rapid psychosocial function screening test identified treatment failure in HIV+ African youth

AIDS Care. 2012;24(6):722-7. doi: 10.1080/09540121.2011.644233. Epub 2012 Jan 31.


Psychosocial dysfunction in older children and adolescents is common and may lead to nonadherence to HIV treatments. Poor adherence leads to HIV treatment failure and the development of resistant virus. In resource-limited settings where treatment options are typically limited to only one or two available lines of therapy, identification of individuals at highest risk of failure before failure occurs is of critical importance. Rapid screening tools for psychosocial dysfunction may allow for identification of those children and adolescents who are most likely to benefit from limited psychosocial support services targeted at preventing HIV treatment failure. The Pediatric Symptom Checklist (PSC) is used in high resource settings for rapid identification of at-risk youth. In 692 HIV-infected treated children (ages of 8-< 17 years) in Botswana, having a high score on the PSC was associated with having virologic failure (OR 1.7, 95% CI: 1.1-2.6). The PSC may be a useful screening tool in pediatric HIV.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Affective Symptoms / diagnosis*
  • Affective Symptoms / epidemiology
  • African Continental Ancestry Group
  • Anti-HIV Agents
  • Botswana / epidemiology
  • Checklist
  • Child
  • Child Health Services / organization & administration*
  • Female
  • HIV Seropositivity / drug therapy
  • HIV Seropositivity / epidemiology
  • HIV Seropositivity / psychology*
  • Humans
  • Male
  • Mass Screening / methods*
  • Medication Adherence / psychology*
  • Medication Adherence / statistics & numerical data
  • Prevalence
  • Psychological Tests
  • Social Behavior Disorders / diagnosis*
  • Social Behavior Disorders / epidemiology
  • Surveys and Questionnaires
  • Treatment Failure


  • Anti-HIV Agents