Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus

Int J Med Microbiol. 2012 Mar;302(2):108-16. doi: 10.1016/j.ijmm.2011.12.001. Epub 2012 Jan 30.


Aspergillus fumigatus is an all-important pathogenic fungus and is known for its angiotropism. When it invades human organs, A. fumigatus makes direct contact with blood and its components by causing inflammation and invading vascular structures. To learn the effect of its contact with blood on the development of infection, we examined the effect of serum on A. fumigatus growth. In Dulbecco's modified Eagle's medium containing 10% fetal bovine serum, hyphal tip growth was accelerated, forming a thickened and well-networked biofilm associated with extracellular matrix, and fetuin A was identified as the active component in the serum that accelerates fungal growth leading to formation of a community. These results suggest that fetuin A is a novel accelerator of the growth of A. fumigatus and that it participates in the formation of thick biofilm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / physiology*
  • Aspergillus fumigatus / ultrastructure
  • Biofilms / drug effects*
  • Biofilms / growth & development*
  • Cattle
  • Humans
  • Hyphae / metabolism
  • Hyphae / ultrastructure
  • Polysaccharides / metabolism
  • alpha-2-HS-Glycoprotein / metabolism
  • alpha-2-HS-Glycoprotein / pharmacology*


  • Polysaccharides
  • alpha-2-HS-Glycoprotein