Anti-glycation effect of gold nanoparticles on collagen

Biol Pharm Bull. 2012;35(2):260-4. doi: 10.1248/bpb.35.260.


Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including anti-inflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3 ± 4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Collagen / chemistry*
  • Glycation End Products, Advanced / chemistry*
  • Glycosylation
  • Gold / chemistry*
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure


  • Glycation End Products, Advanced
  • Gold
  • Collagen