DNA microarray analysis of transcriptional responses of rats housed on solid and grid cage flooring

J Toxicol Sci. 2012 Feb;37(1):219-22. doi: 10.2131/jts.37.219.


We performed DNA microarray analysis on the white blood cells (WBCs) of rats housed on solid and grid cage flooring. The expression levels of 50 genes were found to increase more than 2-fold in the WBCs on grid cage flooring, including many genes encoding proteins involved in inflammatory or immune responses. It is therefore suggested that the health and welfare of laboratory rats is likely to be improved by housing rats on solid floors.

MeSH terms

  • Animal Welfare
  • Animals
  • Gene Expression Profiling*
  • Housing, Animal*
  • Leukocytes / metabolism
  • Male
  • Oligonucleotide Array Sequence Analysis
  • Rats
  • Rats, Inbred F344