No association between infections, HLA type and other transplant-related factors and risk of cutaneous squamous cell carcinoma in solid organ transplant recipients

Acta Derm Venereol. 2012 Nov;92(6):609-14. doi: 10.2340/00015555-1271.


Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immuno-suppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant associations with any infectious agents, or with number and timing of infections, specific HLA-type, donor characteristics, or other transplant characteristics and risk of post-transplant SCC. These results suggest that risk of post-transplant SCC is neither closely related to specific post-transplant infectious disorders, nor to the infectious load or specific HLA types.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Carcinoma, Squamous Cell / etiology*
  • Carcinoma, Squamous Cell / immunology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Communicable Diseases / etiology*
  • Communicable Diseases / immunology
  • Female
  • HLA Antigens / immunology*
  • Histocompatibility*
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Infant
  • Infant, Newborn
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Organ Transplantation / adverse effects*
  • Risk Assessment
  • Risk Factors
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / immunology
  • Sweden
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • HLA Antigens
  • Immunosuppressive Agents