Grading liposarcomas with PET using [18F]FDG

J Comput Assist Tomogr. Nov-Dec 1990;14(6):960-2. doi: 10.1097/00004728-199011000-00017.

Abstract

Five patients with liposarcomas of the thigh were studied using positron emission tomography (PET) with [18F]2-deoxy-2-fluoroglucose (FDG). There were three low-grade tumors (all National Cancer Institute Grade 1 myxoid liposarcomas) and two high-grade tumors (both pleomorphic liposarcomas, Grades 2 and 3). The low-grade liposarcomas were easily identified with an average dose uptake ratio (DUR) of 1.38 +/- 0.045 (mean +/- SD). The high-grade lesions were more avid for FDG with a mean DUR of 2.45 +/- 0.24. There was a significant difference (p = 0.004) in the DUR for the two groups and the histological grade of malignancy was highly correlated with the DUR for FDG (Rho = 0.89). These findings suggest that FDG-PET may be useful for distinguishing between low-grade and high-grade liposarcomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Deoxyglucose / analogs & derivatives*
  • Fluorodeoxyglucose F18
  • Humans
  • Liposarcoma / diagnostic imaging*
  • Soft Tissue Neoplasms / diagnostic imaging*
  • Thigh
  • Tomography, Emission-Computed*

Substances

  • Fluorodeoxyglucose F18
  • Deoxyglucose