Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme

Curr Opin Immunol. 2012 Feb;24(1):77-83. doi: 10.1016/j.coi.2012.01.005. Epub 2012 Jan 31.


The immunoproteasome is a specific proteasome isoform induced by interferons. Its proteolytic function has been almost exclusively connected with the adaptive immune response and improved MHC class I antigen presentation. However, IFN-signaling also exposes cells to oxidative stress with concomitant production of nascent-oxidant damaged poly-ubiquitylated proteins. Here we discuss how immunoproteasomes protect cells against accumulation of toxic protein-aggregates and how i-proteasomes dysfunction associates with different diseases. We propose that the immunoproteasome has a central function at the interface between the innate and adaptive immune response and that its predominant protective innate function determines its favorable role in the adaptive immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / immunology*
  • Animals
  • Antigen Presentation / immunology
  • Humans
  • Immunity, Innate / immunology*
  • Oxidative Stress
  • Proteasome Endopeptidase Complex / physiology*
  • Reactive Oxygen Species


  • Reactive Oxygen Species
  • Proteasome Endopeptidase Complex