Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases

Small. 2012 Apr 10;8(7):997-1000. doi: 10.1002/smll.201102488. Epub 2012 Feb 2.

Abstract

Nanoparticles containing stable holmium ((165) Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield (166) Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the (166) Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Drug Carriers / administration & dosage
  • Drug Carriers / chemistry*
  • Female
  • Holmium / chemistry*
  • Humans
  • Mice
  • Mice, Nude
  • Microscopy, Electron, Transmission
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use*
  • Nanoparticles / ultrastructure
  • Neutrons
  • Ovarian Neoplasms / drug therapy*
  • Xenograft Model Antitumor Assays

Substances

  • Drug Carriers
  • Holmium