Ethyl pyruvate improves healing of colonic anastomosis in a rat model of peritonitis

Surg Innov. 2012 Dec;19(4):394-8. doi: 10.1177/1553350611432158. Epub 2012 Jan 31.

Abstract

Background: This study was designed to evaluate the effects of ethyl pyruvate (EP) on wound healing in primary colonic anastomoses in intraperitoneal sepsis.

Methods: Standard left colon resection and end-to-end anastomosis were performed on 30 rats. They were grouped as control (C)--no further treatment; sepsis (S)--received 2 mL Escherichia coli (ATCC 25922) intraperitoneally (IP), and after 5 hours, standard resection and anastomosis were performed; or sepsis-group treated with EP (S-EP)--received 2 mL E coli IP, after 5 hours, standard resection and anastomosis were performed and treated with EP 50 mg/kg IP for 7 days. On the postoperative day 7, the animals were sacrificed.

Results: The anastomosis bursting pressure in group S was significantly lower than in the other groups. There were no differences between groups C and S-EP. Tissue hydroxyproline concentrations in group C were significantly higher than in group S.

Conclusions: EP administration prevented intraperitoneal sepsis-induced impaired anastomotic healing of colon.

MeSH terms

  • Analysis of Variance
  • Anastomosis, Surgical / methods*
  • Animals
  • Colon / surgery*
  • Disease Models, Animal
  • Hydroxyproline / analysis
  • Male
  • Peritonitis / pathology*
  • Pressure
  • Pyruvates / pharmacology*
  • Rats
  • Rats, Wistar
  • Sepsis / pathology
  • Wound Healing / drug effects*

Substances

  • Pyruvates
  • ethyl pyruvate
  • Hydroxyproline