New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger

Drug Metab Lett. 2012 Mar;6(1):54-9. doi: 10.2174/187231212800229282.

Abstract

Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Deanol / administration & dosage
  • Deanol / pharmacology*
  • Dehydroascorbic Acid / analogs & derivatives
  • Dehydroascorbic Acid / metabolism
  • Dose-Response Relationship, Drug
  • Electron Spin Resonance Spectroscopy
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / pharmacology*
  • Free Radicals / metabolism
  • Hydroxyl Radical / metabolism
  • Microsomes, Liver / metabolism
  • Rats

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Free Radicals
  • Deanol
  • Hydroxyl Radical
  • semidehydroascorbic acid
  • Dehydroascorbic Acid