Singapore Malay Eye Study: rationale and methodology of 6-year follow-up study (SiMES-2)

Clin Exp Ophthalmol. 2012 Aug;40(6):557-68. doi: 10.1111/j.1442-9071.2012.02763.x. Epub 2012 Mar 27.


Background: To describe the rationale and study design of a follow-up epidemiological eye study among Singaporean Malay adults.

Design: Follow-up prospective population-based study.

Participants: Participants of the Singapore Malay Eye Study (SiMES-1), which was conducted from August 2004 to June 2006.

Methods: This is a follow-up study of the 3280 participants who participated in the SiMES-1 and are residing in Singapore. All participants of this follow-up study will undergo various standardized validated questionnaires on socio-demographics, quality of life and impact of visual impairment. Participants will undergo assessment of blood pressure, anthropometry, presenting and best corrected visual acuity, subjective refraction, ocular biometry, slit lamp and dilated eye examination, Goldmann tonometry, optic disc imaging, digital lens and retinal photography. Retinal tomography, retinal optical coherence topography and fundus autofluorescence will also be performed. Gonioscopy and visual fields examination will be performed on selected individuals.

Main outcome measures: Incidence, risk factors and impact of visual impairment and major eye diseases.

Results: A total of 3280 people who participated in the SiMES-1 will be contacted and invited to participate in this follow-up study. It is estimated that 12.8% of the participants will be deceased and there will be an 80% participation rate for the survivors of SiMES-1 (approximately 2288 participants).

Conclusion: SiMES-2 will be one of the few follow-up epidemiological eye studies among Asians and will determine the cumulative 6-year incidence, progression, risk factors and impact of major eye diseases in Singaporean Malay adults.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asian People / ethnology*
  • Cross-Sectional Studies
  • Disease Progression
  • Epidemiologic Studies
  • Eye Diseases / diagnosis
  • Eye Diseases / ethnology*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Research Design
  • Risk Factors
  • Singapore / epidemiology
  • Surveys and Questionnaires
  • Visually Impaired Persons / statistics & numerical data*