Design of photocontrolled RNA-binding peptidomimetics

Chembiochem. 2012 Mar 5;13(4):515-9. doi: 10.1002/cbic.201100800. Epub 2012 Feb 2.

Abstract

Positively constrained: the first examples of photocontrolled RNA binding peptides are described. The large number of positively charged sides chains in the Rev response element (RRE) of an HIV type I targeting α-helix imposes constraints on the choice of azobenzene-derived crosslinker.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry
  • Binding Sites
  • Cross-Linking Reagents / chemical synthesis
  • Cross-Linking Reagents / chemistry
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Peptides / chemical synthesis
  • Peptides / chemistry*
  • Peptidomimetics / radiation effects*
  • Photochemical Processes*
  • Proteins / chemistry*
  • RNA / chemistry*

Substances

  • Azo Compounds
  • Cross-Linking Reagents
  • Peptides
  • Peptidomimetics
  • Proteins
  • RNA
  • azobenzene