Redox chemistry of green tea polyphenols: therapeutic benefits in neurodegenerative diseases

Mini Rev Med Chem. 2012 May;12(5):380-7. doi: 10.2174/138955712800493906.

Abstract

Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Camellia sinensis / chemistry*
  • Humans
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / metabolism
  • Neuroprotective Agents / chemistry*
  • Neuroprotective Agents / pharmacology*
  • Neuroprotective Agents / therapeutic use
  • Oxidation-Reduction
  • Polyphenols / chemistry*
  • Polyphenols / pharmacology*
  • Polyphenols / therapeutic use

Substances

  • Antioxidants
  • Neuroprotective Agents
  • Polyphenols