Innate immunity to TB: a druggable balancing act

Cell. 2012 Feb 3;148(3):389-91. doi: 10.1016/j.cell.2012.01.026.


Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.

Publication types

  • Comment