A new histone at the centromere?

Daniel R Foltz; P Todd Stukenberg

doi:10.1016/j.cell.2012.01.023

A new histone at the centromere?

Cell. 2012 Feb 3;148(3):394-6. doi: 10.1016/j.cell.2012.01.023.

Authors

Daniel R Foltz¹, P Todd Stukenberg

Affiliation

¹ Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA.

Abstract

The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional properties with canonical histones.

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